Dictyostatin 1 2, a new type of macrocyclic lactone bearing a 22-membered ring system, has been isolated (3.4 × 10–7% yield) from a Republic of Maldives marine sponge in the genus Spongia and found to strongly inhibit growth of the murine P388 lymphocytic leukaemia.
G. R. Pettit, Z. A. Cichacz, F. Gao, M. R. Boyd and J. M. Schmidt, J. Chem. Soc., Chem. Commun., 1994, 1111 DOI: 10.1039/C39940001111
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