By enzymatic coupling with an endopeptidase specific for proline residue, i.e., prolyl endopeptidase, an α-amidated peptide (LH-RH) has been prepared from its acid form precursor without any byproduct.
H. Togame, T. Inaoka and T. Kokubo, J. Chem. Soc., Chem. Commun., 1994, 1107 DOI: 10.1039/C39940001107
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