A one-step control of four stereogenic centres during the Sakurai reaction of 1,8-bis(trimethylsilyl)octa-2,6-diene (BISTRO) to α,β-enones
Abstract
The titanium tetrachloride mediated addition reaction of 1,8-bis(trimethylsilyl)octa-2,6-diene (BISTRO) with open-chain conjugated enones affords syn-anti-syn-4,7-divinyldecane-1, 10-diones with a very high diastereoselectivity.