A short efficient synthesis of the threonine synthase substrate L-O-phosphohomoserine and its C-3 chirally deuteriated isotopomers is described; the route also provides access to L-homoserine and its C-3 chirally deuteriated isotopomers in high yield.
F. Barclay, E. Chrystal and D. Gani, J. Chem. Soc., Chem. Commun., 1994, 815 DOI: 10.1039/C39940000815
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