The conjugate addition of chloride to chiral but-2-enoic imides promoted by BCl3-derivatives proceeds with diastereoisomeric ratios of up to 90 : 10 and affords the corresponding 3-chlorobutanoic imides from which, after mild hydrolysis, the 3-chlorobutanoic acid is obtained.
G. Cardillo, A. de Simone, L. Gentilucci and C. Tomasini, J. Chem. Soc., Chem. Commun., 1994, 735 DOI: 10.1039/C39940000735
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