The squalestatins, inhibitors of squalene synthase and potent antimicrobial agents, have potential both as cholesterol-lowering drugs and as antibiotics; using potentiometry and circular dichroism, we show that squalestatin-1 has a much higher affinity for Ca2+ than citrate, and readily inserts into SDS micelles (a model membrane), processes which may be relevant to its mechanism of action.
W. Bal, A. F. Drake, M. Jezowska-Bojczuk, H. Kozlowski, L. D. Pettit and P. J. Sadler, J. Chem. Soc., Chem. Commun., 1994, 555 DOI: 10.1039/C39940000555
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