Remarkable dipolarophilicity of nitrile function uncovered in the 1,3-dipolar cycloaddition reaction of homoadamantane-incorporated nitrones. A direct and facile route to Δ4-1,2,4-oxadiazoline (2,3-dihydro-1,2,4-oxadiazole) derivatives
Abstract
Various nitriles, including unactivated nitriles, underwent a 1,3-dipolar cycloaddition reaction with homoadamantane-incorporated nitrones to afford Δ4-1,2,4-oxadiazoline derivatives.