Two substituents on C-4 drastically reduce the tendency of 1,2-dithiolane to polymerize, whereas they do not significantly alter the reactivity of the remote disulfide; the dithiolanes 1a–e show high reactivity towards the carbon nucleophile EtMgBr as expected for the enzyme-bound lipoic acid.
M. Tazaki, H. Tanabe, S. Nagahama and M. Takagi, J. Chem. Soc., Chem. Commun., 1994, 291 DOI: 10.1039/C39940000291
To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.
If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.
Read more about how to correctly acknowledge RSC content.
Please wait while we load your content...