Electrochemical oxidative determination of thimerosal in soft contact lens care solutions by cyclic voltammetry

Abstract

The electrochemical oxidation of thimerosal (TMS) was studied by cyclic voltammetry on a rotating glassy carbon disc electrode. The best results were obtained for TMS solutions adjusted to pH 4.0 with acetate buffer solutions and a scan rate of 40 mV s^–1. The limit of detection obtained ranged from 0.1 to 0.09 µg ml^–1 and the method was applied to the determination of TMS in soft contact lens care solutions with good results, the accuracy required being about 5–10%.