Issue 6, 1994

Spectrofluorimetric determination of nalidixic acid based on host–guest complexation with γ-cyclodextrin

Abstract

The characteristics of host–guest complexation between γ-cyclodextrin and nalidixic acid were investigated by fluorescence spectrometry. A 1 : 1 stoichiometry of the complex was established and an association constant of 292 l mol–1 was calculated by using the changes in the fluorescence of nalidixic acid that occurred when it was included in the hydrophobic cyclodextrin cavity. A spectrofluorimetric method for the determination of nalidixic acid was developed, with a range of application between 0.1 and 2 µg ml–1. The method was applied satisfactorily to the determination of nalidixic acid in a pharmaceutical preparation and in urine.

Article information

Article type
Paper

Analyst, 1994,119, 1215-1219

Spectrofluorimetric determination of nalidixic acid based on host–guest complexation with γ-cyclodextrin

I. Durán-Merás, A. M. de la Peña, F. Salinas and I. R. Cáceres, Analyst, 1994, 119, 1215 DOI: 10.1039/AN9941901215

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements