Issue 9, 1994

Enantioseparation of carbonyl compounds by high-performance liquid chromatography based on diastereomer formation

Abstract

The optically active fluorescent tagging reagents, 4-(2-carbazoylpyrrolidin-1-yl)-7-nitro-2,1,3-benzoxadiazole [R(+)-and S(–)-NBD-ProCZ] and 4-(2-carbazoylpyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole [R(+)-and S(–)-DBD-ProCZ], react with enantiomers of aldehydes and ketones under mild conditions (65 °C for 10 min) in the presence of trichloroacetic acid (TCA). Fluorescent hydrazone diastereomers derived from some chiral ketones were separated by reversed-phase and/or normal-phase high-performance liquid chromatography, on achiral columns.

Article information

Article type
Paper

Anal. Proc., 1994,31, 265-268

Enantioseparation of carbonyl compounds by high-performance liquid chromatography based on diastereomer formation

T. Toyo'oka and Y. Liu, Anal. Proc., 1994, 31, 265 DOI: 10.1039/AI9943100265

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