Several amino acids have been derivatized with a fluorescent probe, 3-(4-tetrazolebenzoyl)-2-quinolinecarboxaldehyde (TBQCA), to give intensely fluorescent isoindole derivatives. The usefulness of this reagent for the capillary electrophoretic analysis of low levels of amino acids using laser fluorescence detection has been shown. Minimum detection concentrations were found to be as low as 5 × 10–10 mol dm–3.
P. Camilleri, D. Dhanak, M. Druges and G. N. Okafo, Anal. Proc., 1994, 31, 99 DOI: 10.1039/AI9943100099
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