The six eclipsed sidechains in scyllo-inositol hexamethyl ether. A molecular mechanics study

Abstract

The most stable conformation of the hexamethyl ether of scyllo-inositol (all-trans-cyclohexan-1, 2, 3, 4, 5, 6-hexol) is calculated to be the one with six equatorial methoxy groups with in each case the oxygen-methyl bond eclipsing the adjacent axial carbon-hydrogen bond. Eclipsed bonds are also calculated for other inositol hexamethyl ether stereoisomers. Results contrast with the conformations of the equivalent hexaethylcyclohexane.