Issue 21, 1993

Synthesis of 5-(acylethynyl)uracils and their corresponding 2′-deoxyribonucleosides through palladium-catalysed reactions

Abstract

Good yields of the title uracils were obtained by using the palladium-catalysed reaction between 5-iodo-2,4-dimethoxypyrimidine and substituted propargylic alcohols rather than the corresponding ketones. The same strategy works for coupling with the 5-iodo-2′-deoxyuridines.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1993, 2657-2663

Synthesis of 5-(acylethynyl)uracils and their corresponding 2′-deoxyribonucleosides through palladium-catalysed reactions

N. G. Kundu and S. K. Dasgupta, J. Chem. Soc., Perkin Trans. 1, 1993, 2657 DOI: 10.1039/P19930002657

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