A novel and convenient route to the thermodynamically unstable ketone 11via the cyclopentanone 8 which was synthesised by palladium-mediated ring expansion of the chiral siloxyvinylcyclobutanes 9 and 10 has been developed. This leads to an enantioselective total synthesis of (+)- laurene 1.
H. Nemoto, M. Nagamochi and K. Fukumoto, J. Chem. Soc., Perkin Trans. 1, 1993, 2329 DOI: 10.1039/P19930002329
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