9-(1-Fluoro-5-hydroxypentan-2-yl)-9H-guanine: synthesis and evaluation of antiviral activity
Abstract
5-Fluoro-4-tosyloxypentyl pivalate has been synthesized in four steps from 2-(fluoromethyl)tetrahydrofuran. Condensation with 2-amino-6-chloropurine gave the N-9 derivative, which was converted via the 6-methoxy analogue into 9-(1-fluoro-5-hydroxypentan-2-yl)-9H-guanine. The latter was evaluated, and found inactive, in a large variety of antiviral assays.