Total synthesis of (+)-kifunensine, a potent glycosidase inhibitor
Abstract
(+)-Kifunensine, a potent inhibitor of mannosidase I, has been synthesized in 13 steps from chlorobenzene by microbial oxygenation with Pseudomonas putida 39D and stereocontrolled peripheral functionalization of cis-3-chlorocyclohexa-3,5-dienediol 3.