Synthesis of 2,3,6,7-tetrahydro- and 2,3,4,5,6,7-hexahydro-1H-1,4-diazepines via a tandem Michael-type addition–intramolecular aza-Wittig sequence
Abstract
Intramolecular aza-Wittig reaction of azides derived from 1, 2-amino azides and α, β-unsaturated ketones leads to 2, 3, 6, 7-tetrahydro-1H-1, 4-diazepines. Reduction of these compounds with lithium aluminium hydride atfords the corresponding saturated heterocycles.