Issue 4, 1993

Synthesis of α-alkyl-α-benzyl amino acid derivatives, via the diastereoselective alkylation of (3S,5R)-N,3-dibenzyl-3,4,5,6-tetrahydro-5-phenyl-1,4-oxazin-2-one

Abstract

(3S,5R)-N,3-Dibenzyl-3,4,5.6-tetrahydro-5-phenyl-1,4-oxazin-2-one, derived from L-phenylalanine and phenacyl bromide, was alkylated in a diastereoselective manner to give a range of α-alkylated phenylalanine derivatives.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1993, 477-481

Synthesis of α-alkyl-α-benzyl amino acid derivatives, via the diastereoselective alkylation of (3S,5R)-N,3-dibenzyl-3,4,5,6-tetrahydro-5-phenyl-1,4-oxazin-2-one

A. N. Boa, A. L. Guest, P. R. Jenkins, J. Fawcett, D. R. Russell and D. Waterson, J. Chem. Soc., Perkin Trans. 1, 1993, 477 DOI: 10.1039/P19930000477

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