Fungal metabolites. Part 8. Primary structures of antibiotic peptides, hypelcin A-I, A-II, A-III, A-IV, A-V, A-VI, A-VII, A-VIII and A-IX from Hypocrea peltata

Abstract

Hypelcin A is a mixture of antibiotic peptides produced by Hypocrea peltata. Hypelcin A-I, A-II, AIII, A-IV, A-V, A-VI, A-VII, A-VIII and A-IX are components of this mixture purified by reversedphase high-performance liquid chromatography. The amino acid sequences of these peptides were determined by fast-atom bombardment mass spectrometry and fast-atom bombardment mass spectrometry/mass spectrometry with the help of NMR spectroscopy. The relative molecular masses of these peptides were all ∼2000 and their structures were very similar.