1-Substituted 1,2-dihydropyrrolizin-3-ones can be obtained from pyrrolizin-3-one 2 by conjugate nucleophilic addition or electrophilic addition reactions; the 1-chloro compound 9 obtained by the latter method is used as a key intermediate in a six-step synthesis of the title compound 3 from 4-acetoxymethylpyridine-N-oxide.
H. McNab and C. Thornley, J. Chem. Soc., Chem. Commun., 1993, 1570 DOI: 10.1039/C39930001570
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