Cerium(III) chloride mediated addition of Grignard reagents to nitroalkanes: synthesis of N,N-disubstituted hydroxylamines
Abstract
Reaction of nitroalkanes with Grignard reagents, in the presence of anhydrous CeCl3 in tetrahydrofuran at –78 °C, affords N,N-disubstituted hydroxylamines in fair to good yields, depending on the nature of the reagent used.