Issue 13, 1993

Facile synthesis of potent HIV-1 protease inhibitors containing a novel pseudo-symmetric dipeptide isostere

Abstract

A series of potent inhibitors of the HIV-1 protease containing a novel pseudo-symmetric dipeptide isostere 3 was synthesized via ring opening of a protected epoxide with various substituted hydrazines.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1993, 1052-1053

Facile synthesis of potent HIV-1 protease inhibitors containing a novel pseudo-symmetric dipeptide isostere

H. L. Sham, D. A. Betebenner, C. Zhao, N. E. Wideburg, A. Saldivar, D. J. Kempf, J. J. Plattner and D. W. Norbeck, J. Chem. Soc., Chem. Commun., 1993, 1052 DOI: 10.1039/C39930001052

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