Issue 9, 1993

Site-specific disulfide bridges in oligodeoxyribonucleotide duplexes containing 6-mercaptopurine and 4-thiothymine bases

Abstract

A self complementary oligodeoxynucleotide duplex containing 6-thio-2′-deoxyinosine and 4-thio-2′-deoxythymidine undergoes cross-linking to form interstrand disulfide bridges under aerobic conditions; the reaction is reversed by dithiothreitol.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1993, 779-780

Site-specific disulfide bridges in oligodeoxyribonucleotide duplexes containing 6-mercaptopurine and 4-thiothymine bases

J. Milton, B. A. Connolly, T. T. Nikiforovc and R. Cosstick, J. Chem. Soc., Chem. Commun., 1993, 779 DOI: 10.1039/C39930000779

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