Site-specific disulfide bridges in oligodeoxyribonucleotide duplexes containing 6-mercaptopurine and 4-thiothymine bases
Abstract
A self complementary oligodeoxynucleotide duplex containing 6-thio-2′-deoxyinosine and 4-thio-2′-deoxythymidine undergoes cross-linking to form interstrand disulfide bridges under aerobic conditions; the reaction is reversed by dithiothreitol.