Issue 7, 1993

Efficient total synthesis of racemic and optically active cyclobut-A and simple analogues

Abstract

Rapid synthesis of the potent antiviral agent, cyclobut-A, 1a, from the inexpensive starting materials maleic anhydride and acetylene, in both racemic and optically active forms, is described; the route also allows for the preparation of several hydroxylated and keto analogues in good overall yield.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1993, 589-591

Efficient total synthesis of racemic and optically active cyclobut-A and simple analogues

M. E. Jung and A. W. Sledeski, J. Chem. Soc., Chem. Commun., 1993, 589 DOI: 10.1039/C39930000589

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