Rapid synthesis of the potent antiviral agent, cyclobut-A, 1a, from the inexpensive starting materials maleic anhydride and acetylene, in both racemic and optically active forms, is described; the route also allows for the preparation of several hydroxylated and keto analogues in good overall yield.
M. E. Jung and A. W. Sledeski, J. Chem. Soc., Chem. Commun., 1993, 589 DOI: 10.1039/C39930000589
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