Conformational properties of octahydroxy[1.4]metacyclophanes with unsubstituted methylene bridges
Abstract
Octahydroxy[1.4]metacyclophanes with long alkyl substituents on the aromatic rings have been prepared; the preferred conformation of the tetrahexyl derivative 8 in CDCl3 is a cone and its free energy of activation, ΔG‡298, for the ring inversion has been determined to be 12.0 kcal mol–1(1 cal = 4.184 J) using dynamic 1H NMR spectroscopy and complete line shape analysis.