Tutorial review—Multi-electrode array detectors in high-performance liquid chromatography: a new dimension in electrochemical analysis

Abstract

Liquid chromatography has been evolving rapidly over recent years and now provides a fast, accurate and reliable method for determining the identity and concentration of a wide range of compounds. Recent advances in detector systems include the introduction of a multi-electrode high efficiency electrochemical sensor, which enables compounds to be resolved as a function of their individual oxidation potential. Combining such array sensors with gradient chromatography increases both the range of compounds in samples that can be identified in a short period of time and the confidence with which they can be matched to known standards. This paper introduces the field of three-dimensional chromatography using electrochemical array detectors and provides examples of where this new technology is currently being used.