Electroreduction of some potential antimicrobial thiosemicarbazide derivatives of quinazolin-4(3H)-one

Abstract

Polarographic data for a series of 3-phenyl-2-substituted thiocarbamoylhydrazonomethylquinazolin-4(3H)-ones (with antimicrobial activity), in 50% ethanolic aqueous buffers covering a wide range of pH are reported and discussed. A mechanism interpreting the electrode process, in both acidic and alkaline media, is proposed and confirmed via the identification of CPE products, Hammett's σ–E_½ relation and pK_a determination.