Issue 22, 1992

A practical synthesis of (+)-muscarine from L-rhamnose

Abstract

A practical seven-step synthesis of muscarine tosylate {[(2S,4R,5S)-4-hydroxy-5-methyltetrahydrofuran-2-ylmethyl](trimethyl)ammonium tosylate} from L-rhamnose is described, which does not require the use of any protecting group.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1992, 3023-3027

A practical synthesis of (+)-muscarine from L-rhamnose

S. J. Mantell, G. W. J. Fleet and D. Brown, J. Chem. Soc., Perkin Trans. 1, 1992, 3023 DOI: 10.1039/P19920003023

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