Issue 20, 1992

Synthesis of two 6′α-fluorocarbocyclic nucleosides and incorporation into short segments of DNA

Abstract

The 6′-fluorocarbocyclic nucleosides 1 and 2 have been synthesized from the bicyclic ketone 3 in 16 and 2% yield respectively. The nucleoside 1 has been incorporated into short chains of DNA using an automated synthesizer and these oligonucleotides have been shown to hybridize with (fluorine containing) complementary strands.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1992, 2633-2641

Synthesis of two 6′α-fluorocarbocyclic nucleosides and incorporation into short segments of DNA

A. N. Payne and S. M. Roberts, J. Chem. Soc., Perkin Trans. 1, 1992, 2633 DOI: 10.1039/P19920002633

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