The 6′-fluorocarbocyclic nucleosides 1 and 2 have been synthesized from the bicyclic ketone 3 in 16 and 2% yield respectively. The nucleoside 1 has been incorporated into short chains of DNA using an automated synthesizer and these oligonucleotides have been shown to hybridize with (fluorine containing) complementary strands.
A. N. Payne and S. M. Roberts, J. Chem. Soc., Perkin Trans. 1, 1992, 2633 DOI: 10.1039/P19920002633
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