Simple synthetic route to 4-aminobenzaldehydes from anilines
Abstract
Anilines unsubstituted at the 4-position react under mild conditions in Me2SO–HCl solvent (H+= 0.6 mol dm–3) to give substituted 4-aminobenzaldehydes in high yields; although addition of CuCl2 gives a cleaner product, it is not essential for the reaction. Chloromethyl methyl sulfoxide is thought to be the active species in the reaction.