Forskolin and 7-deacetylforskolin: study of the reactivity behaviour towards different phosphorylating agents

Abstract

Reaction of different phosphorylating agents such as POCl₃, bis-(p-methoxyphenyl) phosphorochloridate, 2-chloro-2-oxo-1,3,2-dioxaphospholane and bis-(trifluoroethyl) phosphite with forskolin gave the corresponding isomers α- and β-1, 9-cyclic phosphates/phosphites. 1,2-Dibromo-2-phenylethylphosphonic acid reacted with forskolin and 7-deacetylforskolin to give forskolin 1-phosphate 17 and 7-deacetylforskolin 7-phosphate 18, respectively.