Base-catalysed deuteriation of (3R)- or (3S)-3-isopropyl-2,5-dimethoxy-3,6-dihydropyrazine in refluxing CH3O2H–2H2O gives the [6-2H2] isotopomer in excellent yield without disturbing the stereogenic centre at C-3, and thus providing convenient and efficient access to a range of (R)- and (S)-α-deuteriated α-amino acids.
J. E. Rose, P. D. Leeson and D. Gani, J. Chem. Soc., Perkin Trans. 1, 1992, 1563 DOI: 10.1039/P19920001563
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