Cyclic dipeptides formed by the self-condensation of amino acids in ethane-1,2-diol comprise readily separable diastereoisomeric mixtures which, in the case of isoleucine, affords three isomers in good yield.
B. Cook, R. R. Hill and G. E. Jeffs, J. Chem. Soc., Perkin Trans. 1, 1992, 1199 DOI: 10.1039/P19920001199
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