Both L-(>95% e.e.) and D-(60% e.e.)4-hydroxy-2-ketoglutarate 3 have been prepared on a mmol scale using 4-hydroxy-2-ketoglutarate (HKG) aldolase. Substrate specificity studies indicate that HKG aldolase isolated from different sources (Escherichia coli, bovine liver and rat liver) is highly specific for both pyruvate and glyoxylate.
N. C. Floyd, M. H. Liebster and N. J. Turner, J. Chem. Soc., Perkin Trans. 1, 1992, 1085 DOI: 10.1039/P19920001085
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