An efficient route to the tropane alkaloids
Abstract
We describe the use of diethylzinc in conjunction with polybromo ketones for the production of oxyallyls, and the interception of these intermediates by furans and methyl pyrrole-N-carboxylate. This methodology allows the production of gramme quantities of tropane alkaloids, and 2-substituted 8-oxabicyclo[3.2.1 ]oct-6-en-3-ones that have been either difficult or impossible to prepare.