The reduction of methyle 4-(4-chlorophenylthio)-3-oxobutanoate 1 by clostridia has been studied. Clostridium pasteurianum ATCC 6013, C. tyrobutyricum DSM 1460 and C. kluyveri NCIB 10680 gave the D-(3S) reduction product 2, whereas C. kluyveri DSM 555 gave the L-(3R) reduction product 3. The products could be obtained in higher optical purities than by yeast reductions.
M. Christen, D. H. G. Crout, R. A. Holt, J. G. Morris and H. Simon, J. Chem. Soc., Perkin Trans. 1, 1992, 491 DOI: 10.1039/P19920000491
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