Structural characterization of platinum(II)–methionine complexes in aqueous solution

Abstract

The presence of isomeric complexes formed in aqueous solutions of platinum(II)–methionine systems has been demonstrated. Proton and ¹³C NMR spectroscopy was found useful for the characterization of such structures and for obtaining the quantitative contributions of the different isomers. Formation of a trimethionine complex was detected and importance of this molecule in the isomerization from trans to cis geometry was postulated. A method of obtaining dimethionineplatinum(II) complexes enriched in cis isomers was developed and the products of this reaction were characterized.