Issue 22, 1992

Studies on the mechanism of action of (5R)-(Z)-6-(1-methyl-1,2,3-triazol-4-ylmethylene)penem-3-carboxylic acid (BRL 427 15), a potent inhibitor of bacterial β-lactamase

Abstract

A novel base catalysed rearrangement of (5R)-(Z)-6-(1-methyl-1,2,3-triazol-4-ylmethylene)penem-3-carboxylic acid (BRL 427 15) is reported together with its implications concerning the mechanism of inactivation of β-lactamases by this compound.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1992, 1663-1664

Studies on the mechanism of action of (5R)-(Z)-6-(1-methyl-1,2,3-triazol-4-ylmethylene)penem-3-carboxylic acid (BRL 427 15), a potent inhibitor of bacterial β-lactamase

N. J. P. Broom, T. H. Farmer, N. F. Osborne and J. W. Tyler, J. Chem. Soc., Chem. Commun., 1992, 1663 DOI: 10.1039/C39920001663

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