Synthesis and X-ray crystal structure of 2-acetyl-9-azabicyclo[4.2.1]nonan-3-one. A conformationally locked s-cis analogue of anatoxin-a
Abstract
2-Acetyl-9-azabicyclo[4.2.1]nonan-3-one 2(‘hydroxyanatoxin-a’), which represents a conformationally locked variant of the s-cis conformer of the potent cholinergic agonist anatoxin-a, is synthesised and characterised; this molecule lacks both nicotinic and muscarinic potency.