Activation of N,N-bis-Boc or N-Boc N-Z amino acids with SOCl2–DMF leads to N-protected N-carboxy amino acid anhydrides, whereas treatment with cyanuric fluoride at low temperature gives mainly N,N-bis-protected amino acid fluorides, which are efficient acylating agents.
J. Savrda and M. Wakselman, J. Chem. Soc., Chem. Commun., 1992, 812 DOI: 10.1039/C39920000812
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