A study of the binding of vancomycin to dipeptides using capillary electrophoresis
Abstract
Capillary electrophoresis (CE) has been used as a rapid technique for the determination of the absolute binding constants of dipeptides with vancomycin in solution; the values obtained for the mucopeptide mimic N-acetyl-D-Ala-D-ala and related dipeptides are in good agreement with values reported in the literature using either differential UV spectrometry or NMR.