Issue 9, 1992

Biosynthesis of the neurotoxin domoic acid by the marine diatom Nitzschia pungens forma multiseries, determined with [13C]-labelled precursors and nuclear magnetic resonance

Abstract

Labelling experiments with [1-13C]acetate and [1,2-13C]acetate provide evidence that the neurotoxin domoic acid, produced by the diatom Nitzschia pungens, is derived by the novel condensation of a geranyl unit with an activated citric acid cycle derivative and subsequent cyclisation to form a proline ring system.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1992, 714-716

Biosynthesis of the neurotoxin domoic acid by the marine diatom Nitzschia pungens forma multiseries, determined with [13C]-labelled precursors and nuclear magnetic resonance

D. J. Douglas, U. P. Ramsey, J. A. Walter and J. L. C. Wright, J. Chem. Soc., Chem. Commun., 1992, 714 DOI: 10.1039/C39920000714

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