The synthesis of a ‘polycyclic peptide’ is described, in which the ε-nitrogens of cyclo-(Lys-Lys-Gly)2 are interconnected by four p-xylyl moieties; this is the first example of the use of multiple cross-linking to generate highly constrained peptides, and NMR spectroscopic evidence indicates the presence of two unusual β-turns that are predicted from molecular modelling studies.
P. D. Bailey, D. G. W. Clarke and G. A. Crofts, J. Chem. Soc., Chem. Commun., 1992, 658 DOI: 10.1039/C39920000658
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