Chemoselective arylation of 2′-deoxyguanosine at N-2 with organoiron complexes

Abstract

2′-Deoxyguanosine has been directly and chemoselectively arylated at the N²-amino function by treatment with tricarbonyl(η⁵-cyclohexadienylium)iron or tricarbonyl[η⁵-2-(n-butyl)cyclohexadienylium]iron cations, followed by decomplexation and dehydrogenation, providing a rapid route to N²-aryl-2′-deoxyguanosine nucleosides.