SCHEDULED MAINTENANCE
An efficient synthesis of the chlorambucil–spermidine conjugate 4 has been achieved via N1,N8-bis-Boc-spermidine and 4 has been shown to crosslink DNA 104 times more efficiently than chlorambucil itself.
G. M. Cohen, P. M. Cullis, J. A. Hartley, A. Mather, M. C. R. Symons and R. T. Wheelhouse, J. Chem. Soc., Chem. Commun., 1992, 298 DOI: 10.1039/C39920000298
To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.
If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.
Read more about how to correctly acknowledge RSC content.
Please wait while we load your content...