Lossen-like rearrangement of N-[α-methylbenzyl(phenyl)phosphinoyl]-O-methylsulfonylhydroxylamine with methylamine: retention of configuration at phosphorus as revealed by X-ray crystallography
Abstract
The diastereoisomers of the title compound 6 rearrange with high stereospecificity on treatment with MeNH2, giving PhMeCHP(O)(NHMe)NHPh in which the migrating phenyl group has been replaced by MeNH2 with retention of configuration at phosphorus.