Issue 12, 1991

Asymmetric construction of α,α–disubstituted cyclobutanones–enantioselective total synthesis of (–)-frontalin

Abstract

Novel access to the chiral, α,α-disubstituted ketone 2-hydroxymethyl-2-methylcyclobutanone was developed, leading to an enantioselective total synthesis of (–)-frontalin, an aggregating pheromone of bark beetles.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1991, 3149-3151

Asymmetric construction of α,α–disubstituted cyclobutanones–enantioselective total synthesis of (–)-frontalin

H. Nemoto, T. Yamada, H. Ishibashi and K. Fukumoto, J. Chem. Soc., Perkin Trans. 1, 1991, 3149 DOI: 10.1039/P19910003149

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