We describe the synthesis of 4-{p-[bis-(2-chloroethyl)amino]phenyl}butanoic acid N-oxide, which is the N-oxide of the anti-cancer drug chlorambucil, and 4-[p-(2(chloroethylsulphinyl)phenyl]butanoic acid. The 3-nitro and 3,6-dinitro derivatives of chlorambucil have also been prepared.
J. Mann and L. A. Shervington, J. Chem. Soc., Perkin Trans. 1, 1991, 2961 DOI: 10.1039/P19910002961
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