The reaction of carboxylic acid esters 1 with in situ generated bromohalomethyllithium (1 : 2 molar ratio) at –78 °C followed by reaction with lithium dialkylcuprate (1 : 1 molar ratio) at O °C, leads, after hydrolysis, to the corresponding α-chloro or α-bromo ketones 3.
J. Barluenga, L. Llavona, M. Yus and J. M. Concellón, J. Chem. Soc., Perkin Trans. 1, 1991, 2890 DOI: 10.1039/P19910002890
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